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November 1, 2001Journal of General Virology

Genetic variability of hepatitis A virus in South America reveals heterogeneity and co-circulation during epidemic outbreaks

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Key result

Phylogenetic analysis of South American HAV isolates revealed they all belong to sub-genotype IA, showing higher heterogeneity and co-circulation than strains from other global regions.

Population

22 distinct hepatitis A virus isolates from Uruguay, Argentina, and Chile, and 21 published sequences from…

Design

Other

Authors

MCMauro Costa‐MattioliVFVirginie FerréSMSerge Monpoeho

Discussion

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Overview

South American HAV heterogeneity supports enhanced regional surveillance; leaves open implications for transmission dynamics and control measures.

Study Design

Type

Observational (n=43)

Multicenter

Yes

Structured PICO

P
Population
Genetic analysis of 22 distinct HAV isolates from Uruguay, Argentina, and Chile, compared with 21 published global strains.
E
Exposure
Genetic analysis of the VP1 amino terminus and the VP1/2A region
O
Outcome
Genetic variability and phylogenetic relationships

Hepatitis A virus strains in South America exhibit high genetic variability and co-circulation of different isolates during outbreaks, all belonging to sub-genotype IA.

Cite This Study

Costa‐Mattioli et al. (2001) conducted an observational in Hepatitis A virus (HAV) (n=43). South American HAV strains vs. Strains isolated in other regions of the world was evaluated on Genetic variability and phylogenetic classification. Phylogenetic analysis of South American HAV isolates revealed they all belong to sub-genotype IA, showing higher heterogeneity and co-circulation than strains from other global regions.

synapsesocial.com/papers/6a9324a91ef0caad2da18d54https://doi.org/10.1099/0022-1317-82-11-2647
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiologic Patterns of Wild-Type Hepatitis A Virus Determined by Genetic Variation1991 · 142 citations
  2. 2Genetic relatedness of hepatitis A virus isolates during a community-wide outbreak2000 · 74 citations
  3. 3Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses1987 · 385 citations
  4. 4Molecular epidemiology of hepatitis A virus in Amsterdam, the Netherlands2001 · 55 citations
  5. 5An outbreak of hepatitis A among south african patients with hemophilia: Evidence implicating contaminated factor VIII concentrate as the source1995 · 45 citations