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April 1, 1997Journal of Medical Virology

Molecular epidemiology of South African strains of hepatitis A virus: 1982–1996

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Key result

Analysis of 21 South African hepatitis A virus isolates revealed >85% nucleic acid sequence identity with genotype I strains, with 81% clustering within subgenotype IB and the remainder in IA.

Population

20 clinical and 1 environmental wild-type isolates of hepatitis A virus (HAV) from South Africa

Design

Other

Authors

MTMaureen B. TaylorNational Health Laboratory Service

Discussion

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Implication

Informs regional HAV surveillance priorities; leaves open needs for expanded studies on transmission and control.

Study Design

Type

Observational (n=21)

Structured PICO

P
Population
21 wild-type isolates (20 clinical, 1 environmental) of hepatitis A virus from South Africa were analyzed to determine genetic relatedness.
C
Comparator
Published sequences for HAV strains from the rest of the world
O
Outcome
Genetic relatedness and genotype classification of the South African HAV isolatessurrogate

South African hepatitis A virus strains belong to genotype I, predominantly subgenotype IB, indicating a circulating population of endemic HAVs from two distinct subgenotypes.

Cite This Study

Maureen B. Taylor (1997) conducted an observational in Hepatitis A virus (n=21). Hepatitis A virus isolates vs. Published sequences for HAV strains was evaluated on Nucleic acid sequence identity and genotype clustering. Analysis of 21 South African hepatitis A virus isolates revealed >85% nucleic acid sequence identity with genotype I strains, with 81% clustering within subgenotype IB and the remainder in IA.

synapsesocial.com/papers/6a9324a91ef0caad2da18d57https://doi.org/10.1002/(sici)1096-9071(199704)51:4<273::aid-jmv3>3.0.co;2-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic relatedness of hepatitis A virus strains recovered from different geographical regions1992 · 498 citations
  2. 2Nucleotide sequence of wild-type hepatitis A virus GBM in comparison with two cell culture-adapted variants1994 · 85 citations
  3. 3Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses1987 · 385 citations
  4. 4Molecular epidemiology of an outbreak of hepatitis A in Italy1995 · 33 citations
  5. 5An outbreak of hepatitis A among south african patients with hemophilia: Evidence implicating contaminated factor VIII concentrate as the source1995 · 45 citations