Why the study?
Does phagocytic stimulation induce formation of platelet-activating factor in human monocyte-derived macrophages and foam cells?
Population
Human monocyte-derived macrophages and cholesterol-loaded macrophage foam cells
Comparison
Phagocytic stimulation with serum-opsonized… vs Non-stimulated cells
Design
Preclinical
Follow-up
30 minutes
Authors
Loading...
Macrophage PAF production during phagocytosis may promote atherothrombosis; leaves open human relevance and clinical implications.
Does phagocytic stimulation induce formation of platelet-activating factor in human monocyte-derived macrophages and foam cells?
Phagocytic activation of macrophages and foam cells induces transient production of PAF, suggesting these cells may serve as a significant source of proatherogenic and prothrombotic mediators in the arterial intima.
Dentan et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: