June 1, 1985The Journal of Biochemistry

Activation of Guinea Pig Peritoneal Macrophages by Platelet Activating Factor (PAF) and Its Agonists1

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Population

Guinea pig peritoneal macrophages and platelets

Design

Preclinical

Authors

HHHidetoshi HayashiNagoya City University IKIchiro KudoShowa University KIKeizo InoueTeikyo University

Discussion

Member takes

Implication

Hypothesis-generating for PAF in macrophage activation; clinical relevance in human cardiovascular inflammation remains to be determined.

Structured PICO

Population

Guinea pig peritoneal macrophages and platelets

Intervention

Platelet activating factor (PAF), its agonists (Compound I, II, III), and antagonist CV3988

Outcome

Macrophage activationsurrogate

PAF and its specific non-metabolizable agonists activate guinea pig peritoneal macrophages, an effect that can be blocked by the PAF antagonist CV3988.

Cite This Study

Hayashi et al. (1985) studied this question.

synapsesocial.com/papers/6a9155ec963a1f481f33f625 https://doi.org/10.1093/oxfordjournals.jbchem.a135232

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Activation of Guinea Pig Peritoneal Macrophages by Platelet Activating Factor (PAF) and Its Agonists1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of Guinea Pig Peritoneal Macrophages by Platelet Activating Factor (PAF) and Its Agonists1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider