Population
Cultured cells (liver epithelial WB and neuroblastoma N1E-115 cells) and rats
Design
Preclinical
Authors
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Supports antisense knockdown of central AT1 receptors in rodents; leaves open translation to human cardiovascular therapies.
Antisense oligonucleotides can effectively attenuate AT1 receptor expression and its associated behavioral functions in vivo.
Sakai et al. (1994) studied this question.
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