May 1, 1992Journal of Neurochemistry

Angiotensin‐Induced Cyclic GMP Production Is Mediated by Multiple Receptor Subtypes and Nitric Oxide in N1E‐115 Neuroblastoma Cells

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Population

Murine neuroblastoma N1E-115 cells

Design

Preclinical

Authors

EZEric ZarahnThe Neurological Institute XYX. YeUniversity of Pennsylvania AAA. AdesChildren's Hospital of Philadelphia

Discussion

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Implication

Hypothesis-generating for dual AT1/AT2 AngII-cGMP signaling via NO in neuronal cells; leaves open in vivo cardiovascular relevance.

Structured PICO

Population

Murine neuroblastoma N1E-115 cells

Intervention

Angiotensin II (AngII) with or without antagonists (DuP 753, [Sarc1,Ile8]-AngII, CGP 42112A) and nitric oxide synthase inhibitor (N-monomethyl-L-arginine)

Outcome

Intracellular cyclic GMP (cGMP) productionsurrogate

Angiotensin II-induced cGMP production in N1E-115 cells is mediated by both AT1 and AT2 receptors and involves intracellular nitric oxide formation.

Cite This Study

Zarahn et al. (1992) studied this question.

synapsesocial.com/papers/6a7b0f6174c579e25f894aba https://doi.org/10.1111/j.1471-4159.1992.tb10076.x

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Angiotensin‐Induced Cyclic GMP Production Is Mediated by Multiple Receptor Subtypes and Nitric Oxide in N1E‐115 Neuroblastoma Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin‐Induced Cyclic GMP Production Is Mediated by Multiple Receptor Subtypes and Nitric Oxide in N1E‐115 Neuroblastoma Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider