AT2 receptor activation leads to protein tyrosine dephosphorylation in N1E-115 cells, supporting a possible role for AT2 receptors in the negative regulation of cell proliferation.
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AT2 receptor dephosphorylation may inhibit proliferation in vitro; hypothesis-generating and requires in vivo confirmation before any clinical relevance.
Nahmias et al. (1995) studied this question.
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