Key result
Angiotensin II rapidly and dose-dependently stimulated nitric oxide release by activating Ca2+/calmodulin-dependent constitutive nitric oxide synthase via AT1 receptors in cultured bovine endothelial cells.
Why the study?
Does Angiotensin II activate constitutive nitric oxide synthase via AT1 receptors in cultured bovine endothelial cells?
Population
Cultured bovine endothelial cells
Comparison
Angiotensin II (10(-9)-10(-6) M) vs Control / various inhibitors
Design
Preclinical
Follow-up
within 1 min
Authors
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ANG II induces endothelial NO via AT1-cNOS in vitro; leaves open relevance to human hypertension.
Does Angiotensin II activate constitutive nitric oxide synthase via AT1 receptors in cultured bovine endothelial cells?
p-value: p=<0.05
Angiotensin II stimulates nitric oxide release by activating Ca2+/calmodulin-dependent constitutive nitric oxide synthase via AT1 receptors in bovine endothelial cells.
Saito et al. (1996) studied this question. Angiotensin II vs. Control was evaluated on Nitrate/nitrite (NOx) production (p=<0.05). Angiotensin II rapidly and dose-dependently stimulated nitric oxide release by activating Ca2+/calmodulin-dependent constitutive nitric oxide synthase via AT1 receptors in cultured bovine endothelial cells.
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