Key result
Angiotensin II significantly augmented nitric oxide synthesis and iNOS mRNA accumulation in interleukin-1 beta-stimulated cultured neonatal rat cardiac myocytes via protein kinase C activation.
Why the study?
Does Angiotensin II augment cytokine-stimulated nitric oxide synthesis in cultured neonatal rat cardiac myocytes?
Population
Cultured neonatal rat cardiac myocytes
Comparison
Angiotensin II (Ang II) incubation vs Unstimulated cells and cells treated with…
Design
Preclinical
Follow-up
24 hours
Authors
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Suggests angiotensin II enhances cytokine-stimulated NO in rat myocytes via PKC; leaves open in vivo and clinical relevance.
Does Angiotensin II augment cytokine-stimulated nitric oxide synthesis in cultured neonatal rat cardiac myocytes?
Angiotensin II upregulates IL-1 beta-induced iNOS expression and NO production in cardiac myocytes, mediated at least partially via activation of protein kinase C.
Ikeda et al. (1995) studied Cultured neonatal rat cardiac myocytes. Angiotensin II vs. Unstimulated cells was evaluated on Nitric oxide (NO) production and iNOS mRNA expression. Angiotensin II significantly augmented nitric oxide synthesis and iNOS mRNA accumulation in interleukin-1 beta-stimulated cultured neonatal rat cardiac myocytes via protein kinase C activation.
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