What is the clinical evidence from this study?

Study design: Other. Intervention: Angiotensin II. Primary outcome: Renal NOS III mRNA and protein synthesis.

What question did this study set out to answer?

To determine the effects of acute and chronic ANGII on NOS III synthesis in rat kidneys.

January 1, 1998HypertensionOpen Access

Angiotensin II Stimulates Synthesis of Endothelial Nitric Oxide Synthase

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Key result

Acute angiotensin II infusion increased renal NOS III mRNA by 70%, while chronic infusion increased NOS III protein by 90% in rats.

Authors

BHBettye Sue HenningtonTougaloo College HZHuimin ZhangJiangsu University MMM. Todd MillerUniversity of Mississippi Medical Center

Discussion

Member takes

Implication

Does not support changes in clinical ANGII management; leaves open NOS III translation from rat models to human hypertension.

Key Points

To determine the effects of acute and chronic ANGII on NOS III synthesis in rat kidneys.
Performed in rats to assess mRNA and protein synthesis of NOS III after ANGII elevation.
Captopril (20 microg/kg/min) was administered intravenously to inhibit ANGII production.
Acute infusion of ANGII (8 ng/kg/min) for 110 minutes and chronic infusion (5 ng/kg/min) for 10 days were conducted.
Acute ANGII increased renal NOS III mRNA by 70%, but did not affect protein levels.
Chronic ANGII infusion increased NOS III protein by 90%, despite no change in mRNA levels.
Acute and chronic ANGII affected renal plasma flow and GFR differently, indicating divergent effects.

PICO

Population

Rats subjected to acute or chronic angiotensin II infusion to evaluate renal NOS III synthesis.

Intervention / Comparator

Angiotensin II (Acute: 8 ng/kg/min; Chronic: 5 ng/kg/min)

Primary Outcome

Renal NOS III mRNA and protein synthesis

Cite This Study

Hennington et al. (1998) studied this question. Angiotensin II was evaluated on Renal NOS III mRNA and protein synthesis. Acute angiotensin II infusion increased renal NOS III mRNA by 70%, while chronic infusion increased NOS III protein by 90% in rats.

synapsesocial.com/papers/6a2a173d9b8d83ce413f068b https://doi.org/10.1161/01.hyp.31.1.283

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January 1, 1998HypertensionOpen Access

Angiotensin II Stimulates Synthesis of Endothelial Nitric Oxide Synthase

View Full Paper

Ask AI

Bookmark

Key result

Acute angiotensin II infusion increased renal NOS III mRNA by 70%, while chronic infusion increased NOS III protein by 90% in rats.

Authors

BHBettye Sue HenningtonTougaloo College HZHuimin ZhangJiangsu University MMM. Todd MillerUniversity of Mississippi Medical Center

Discussion

Member takes

Implication

Does not support changes in clinical ANGII management; leaves open NOS III translation from rat models to human hypertension.

Key Points

To determine the effects of acute and chronic ANGII on NOS III synthesis in rat kidneys.
Performed in rats to assess mRNA and protein synthesis of NOS III after ANGII elevation.
Captopril (20 microg/kg/min) was administered intravenously to inhibit ANGII production.
Acute infusion of ANGII (8 ng/kg/min) for 110 minutes and chronic infusion (5 ng/kg/min) for 10 days were conducted.
Acute ANGII increased renal NOS III mRNA by 70%, but did not affect protein levels.
Chronic ANGII infusion increased NOS III protein by 90%, despite no change in mRNA levels.
Acute and chronic ANGII affected renal plasma flow and GFR differently, indicating divergent effects.

PICO

Population

Rats subjected to acute or chronic angiotensin II infusion to evaluate renal NOS III synthesis.

Intervention / Comparator

Angiotensin II (Acute: 8 ng/kg/min; Chronic: 5 ng/kg/min)

Primary Outcome

Renal NOS III mRNA and protein synthesis

Cite This Study

synapsesocial.com/papers/6a2a173d9b8d83ce413f068b https://doi.org/10.1161/01.hyp.31.1.283

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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