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December 1, 1945The Journal of Experimental MedicineOpen Access

Enduring Immunity Following Vaccination of Mice With Formalin-Inactivated Virus of Russian Spring-Summer (Far Eastern, Tick-Borne) Encephalitis

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Why the study?

Does vaccination with formalin-inactivated virus of Russian spring-summer encephalitis induce lasting immunity in albino mice?

Population

Albino mice

Design

Preclinical

Follow-up

almost throughout life

Authors

JCJ. CasalsPOPeter K. Olitsky

Discussion

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Overview

Supports inactivated vaccines for durable immunity in mice; leaves open human translation for encephalitis prevention.

Structured PICO

Does vaccination with formalin-inactivated virus of Russian spring-summer encephalitis induce lasting immunity in albino mice?

P
Population
Albino mice
I
Intervention
A single course of two intraperitoneal injections of formalin-inactivated virus of Russian spring-summer encephalitis
O
Outcome
Immune state (resistance to peripherally introduced active virus and development of circulating antibody)surrogate

Formalin-inactivated Russian spring-summer encephalitis virus induces lifelong immunity in mice, suggesting active virus is not essential for lasting protection.

Cite This Study

Casals et al. (1945) studied this question.

synapsesocial.com/papers/6a705196abc331a858079812https://doi.org/10.1084/jem.82.6.431
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Also Consider

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  1. 1INDUCED RESISTANCE OF THE CENTRAL NERVOUS SYSTEM TO EXPERIMENTAL INFECTION WITH EQUINE ENCEPHALOMYELITIS VIRUS1943 · 22 citations
  2. 2INTRAPERITONEAL AND INTRACEREBRAL ROUTES IN SERUM PROTECTION TESTS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS1938 · 24 citations
  3. 3Laboratory Methods of the United States Army1944 · 4 citations
  4. 4INDUCED RESISTANCE OF THE CENTRAL NERVOUS SYSTEM TO EXPERIMENTAL INFECTION WITH EQUINE ENCEPHALOMYELITIS VIRUS1942 · 29 citations
  5. 5ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS1936 · 18 citations