Population
Mice vaccinated against W.E.E. virus
Comparison
Intracerebral challenge dose of viral variants vs Non-vaccinated mice
Design
Preclinical
Follow-up
up to 127 days
Authors
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Suggests compartmentalized CNS immunity in vaccinated mice; leaves open relevance to human WEE vaccine strategies.
Intracerebral challenge with W.E.E. virus in vaccinated mice induces a strong local immune response characterized by high and persistent neutralizing antibody levels in the brain.
R. Walter Schlesinger (1949) studied this question.
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