This review provides treatment guidelines and principles for selecting antihypertensive agents in patients with diabetes mellitus and mild to moderate hypertension.
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Offers principles for antihypertensive selection in diabetic mild-moderate hypertension; leaves open prospective validation in contemporary cohorts.
The treatment of mild to moderate hypertension in patients with diabetes mellitus is reviewed in this article. The effect of diabetic hypertension on the heart and kidney is discussed. Treatment guidelines for diabetic hypertension are provided, based on principles derived from the pathophysiology. These principles include choosing an agent that maintains or improves lipids, potassium, insulin sensitivity, and quality of life. Individuals with diabetic hypertension should be assessed for their risk of developing coronary artery disease or nephropathy, since certain antihypertensive agents may help prevent these diseases. A simple method for selecting appropriate drugs is also presented.
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John W. Collins (1991) studied this question.
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