Why the study?
Does growth hormone improve circulating cytokine balance and left ventricular contractile performance in patients with idiopathic dilated cardiomyopathy?
Population
12 patients with idiopathic dilated cardiomyopathy, NYHA class III, mean LV ejection fraction 23.6+/-1.7%
Comparison
Growth hormone 4 IU subcutaneous every other day… vs Control period (randomized crossover design)
Design
RCT, randomized crossover design
Follow-up
3 months
Authors
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GH merits consideration as adjunctive therapy in idiopathic dilated cardiomyopathy; extends cytokine and contractile findings to randomized evidence.
Does growth hormone improve circulating cytokine balance and left ventricular contractile performance in patients with idiopathic dilated cardiomyopathy?
Growth hormone administration in patients with idiopathic dilated cardiomyopathy beneficially modulates the circulating cytokine network and improves left ventricular contractile reserve and exercise capacity.
S. Adamopoulos (2003) studied this question.
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