Why the study?
The study was conducted to investigate risk factors for severe bleeding during warfarin treatment, including the influence of sex, age, comorbidity, and co-medication.
What are the risk factors for severe bleeding in patients initiating warfarin treatment?
Population
232,624 patients ≥ 18 years initiating warfarin treatment in Sweden
Comparison
Risk factors including sex, age, comorbidities, and co-medications
Design
Nationwide registry-based cohort study
Authors
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Women had lower severe bleeding rates on warfarin; leaves open whether sex should modify HAS-BLED scoring in practice.
What are the risk factors for severe bleeding in patients initiating warfarin treatment?
In a large nationwide Swedish cohort, severe bleeding during warfarin treatment occurred at a rate of 37 per 1000 person-years, with male sex, advanced age, prior bleeding, and renal failure identified as significant risk factors.
Rydberg et al. (2020) studied this question.
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