Why the study?
Remnant immunogenicity in decellularized bioprosthetic tissue may require crosslinking, prompting investigation into whether rationally designed crosslinking chemistry can avoid reintroducing calcific degeneration.
Does combining decellularization with engineered crosslinking improve mechanical properties and reduce calcification in bioprosthetic tissue?
Does combining decellularization with engineered crosslinking improve mechanical properties and reduce calcification in bioprosthetic tissue?
Combining decellularization with enhanced crosslinking chemistry in xenogeneic pericardial tissue reduces calcification and improves mechanical properties, offering a promising approach for extending bioprosthetic heart valve longevity.
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Engineered crosslinking of decellularized pericardium may curb calcification; leaves open translation to durable bioprosthetic valves in patients.
Human et al. (2020) studied this question.
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