Answers are grounded in this paper and cite their sources.
Demonstrates direct C-25 hydroxylation of protected 7-dehydrocholesterol hetero Diels-Alder adducts using diverse oxidizing agents, highlighting synthetic pathways to 25-hydroxy-provitamin D3.
was elaborated. The synthesis consists of direct hydroxylation at C-25 of 7-dehydrocholesterol hetero Diels-Alder adducts. The adducts were prepared by [4 + 2] cycloaddition of azadienophiles to the steroidal diene. The hydroxylation reactions of adducts were carried out with different dioxiranes or with chromyl trifluoroacetate. The byproducts of these reactions were isolated and identified. The strengths and weaknesses of hydroxylation methods with different oxidizing agents were discussed.
No takes yet. Share an insight, caveat, or question.
Wojtkielewicz et al. (2024) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: