The HOPE (Heart Outcomes Prevention Evaluation) Study and its Consequences
Why the study?
Does Ramipril reduce the risk of future cardiovascular events in high-risk patients without low ventricular ejection fraction or heart failure?
Population
High-risk population of men and women, including many with diabetes, not known to have low ventricular…
Design
Review, randomized
Authors
Discussion
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Member takes
Implication
Supports ramipril for high-risk prevention; leaves open applicability in contemporary cohorts with modern therapies.
Key Points
- To determine whether the ACE inhibitor ramipril and vitamin E reduce cardiovascular events and associated complications in high-risk patients without heart failure.
- Prospective, randomized clinical trial conducted across 19 countries evaluating the ACE inhibitor ramipril and vitamin E.
- Enrolled high-risk men and women, including patients with diabetes, hypertension, or vascular disease, without known heart failure or low ventricular ejection fraction.
- Ramipril, but not vitamin E, significantly reduced the risk of future cardiovascular events across all analyzed subgroups independently of blood pressure changes.
- Ramipril provided both microvascular and macrovascular benefits in diabetic patients while also reducing the incidence of new-onset diabetes.
- Treatment slowed the progression of proteinuria and prevented the development of new microalbuminuria in individuals with renal insufficiency.
Structured PICO
Does Ramipril reduce the risk of future cardiovascular events in high-risk patients without low ventricular ejection fraction or heart failure?
P
Population
High-risk population of men and women, including many with diabetes, not known to have low ventricular ejection fraction or heart failure
I
Intervention
Ramipril
O
Outcome
Future cardiovascular eventshard clinical
The HOPE study demonstrated that Ramipril safely and cost-effectively reduces cardiovascular events in high-risk patients without heart failure, establishing its role in cardiovascular prevention.
Cite This Study
McQueen et al. (2005) studied this question.