Why the study?
Does low-dose controlled-release nifedipine plus candesartan combination therapy improve blood pressure control and renal protection compared to up-titrated candesartan monotherapy in patients with essential hypertension uncontrolled on candesartan 8 mg/day?
Population
Outpatients with essential hypertension who did not achieve target blood pressure with baseline treatment of…
Comparison
Low-dose controlled-release nifedipine plus… vs Up-titrated candesartan (12 mg/day) monotherapy.
Design
RCT, Randomized, double-blind
Authors
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Supports preferring low-dose nifedipine-candesartan combination over up-titration; extends RCT evidence for combinations in uncontrolled essential hypertension.
Does low-dose controlled-release nifedipine plus candesartan combination therapy improve blood pressure control and renal protection compared to up-titrated candesartan monotherapy in patients with essential hypertension uncontrolled on candesartan 8 mg/day?
Low-dose combination therapy of nifedipine CR and candesartan provides superior blood pressure control and reduction in urinary microalbumin excretion compared to up-titrating candesartan monotherapy in patients with uncontrolled essential hypertension.
Hasebe et al. (2005) studied this question.
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