November 13, 2009Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins

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Population

Human apolipoprotein B metabolism

Comparison

Presence of apolipoprotein C-III on lipoproteins vs Absence of apolipoprotein C-III on lipoproteins

Authors

CMCarlos O. MendivilUniversidad de Los Andes CZChunyu ZhengDalian Medical University JFJeremy D. FurtadoHarvard University

Discussion

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Implication

Strengthens rationale for ApoCIII-targeted therapies in dyslipidemia; leaves open effects on clinical cardiovascular outcomes.

Structured PICO

Population

Human apolipoprotein B metabolism (kinetics of 4 very-low-density lipoprotein [VLDL], intermediate-density lipoprotein [IDL], and low-density lipoprotein [LDL] types)

Intervention

Presence of apolipoprotein C-III (apoCIII) on lipoproteins

Comparator

Absence of apolipoprotein C-III (apoCIII) on lipoproteins

Outcome

Kinetics of lipolytic conversion and clearance of VLDL, IDL, and LDLsurrogate

ApoCIII strongly inhibits the hepatic uptake of VLDL and IDL and enhances the conversion of light LDL to dense LDL, highlighting its atherogenic role in lipid metabolism.

Cite This Study

Mendivil et al. (2009) studied this question.

synapsesocial.com/papers/6a7055f46c240de38cdbc481 https://doi.org/10.1161/atvbaha.109.197830

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Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider