Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1989Journal of International Medical Research

Effect of Indobufen on Whole Blood Platelet Aggregation Recorded in the Morning in Patients with Ischaemic Heart Disease

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does evening administration of indobufen reduce morning platelet aggregation in patients with ischaemic heart disease?

Population

12 patients with ischaemic heart disease

Comparison

Indobufen 200 mg administered in the evening vs Baseline

Design

Other

Follow-up

1 day

Authors

ACAngelo CraveriUniversity of MilanLCLuigi ColomboAzienda Socio Sanitaria Territoriale LarianaMLM LanfrediniOspedale San Paolo

Discussion

Loading...

Member takes

Implication

May inform chronotherapy with indobufen in IHD; leaves open whether it improves clinical outcomes, needing RCTs.

Key Points

  • To assess whether evening administration of indobufen suppresses the circadian peak of morning platelet aggregation in patients with ischemic heart disease.
  • Assessed whole blood platelet aggregation induced by ADP (3 µM) and collagen (2 µg/ml) using an impedance method in 12 patients with ischaemic heart disease.
  • Collected measurements at 6:00 a.m., 9:00 a.m., and 12:00 noon on the day prior to and the day following an evening dose of 200 mg indobufen.
  • Untreated patients exhibited a significant increase in platelet aggregation between 6:00 a.m. and 9:00 a.m.
  • Prior evening administration of 200 mg indobufen effectively inhibited this morning surge in platelet aggregability.

Structured PICO

Does evening administration of indobufen reduce morning platelet aggregation in patients with ischaemic heart disease?

P
Population
12 patients with ischaemic heart disease
I
Intervention
Indobufen 200 mg administered in the evening
C
Comparator
Baseline (measurements taken the day before administration)
O
Outcome
Whole blood platelet aggregation induced by ADP (3 microM) and collagen (2 microM/ml) measured at 6.00 a.m., 9.00 a.m. and 12.00 noonsurrogate

Evening administration of indobufen effectively inhibits the morning peak in platelet aggregation in patients with ischemic heart disease.

Cite This Study

Craveri et al. (1989) studied this question.

synapsesocial.com/papers/6a7056c835aa2c282ce1a5d4https://doi.org/10.1177/030006058901700412
View Full Paper
Ask AI
Bookmark
Share