Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 13, 2003Journal of VirologyOpen Access

Classical Swine Fever Virus Interferes with Cellular Antiviral Defense: Evidence for a Novel Function of Npro

View Full Paper
Ask AI
Bookmark
Share

Population

Porcine kidney cell lines and porcine peripheral blood mononuclear cell-derived macrophages

Comparison

Infection with wild-type Classical Swine Fever… vs Mock infection or comparison between wild-type…

Design

Preclinical

Authors

NRNicolas RuggliUniversity of BernJTJon-Duri TratschinUniversity of BernMSMatthias SchweizerUniversity of Bern

Discussion

Loading...

Member takes

Implication

Npro enables CSFV innate immune evasion in cell models; leaves open translation to in vivo pathogenesis or vaccine strategies.

Structured PICO

P
Population
Porcine kidney cell lines (SK-6, PK-15) and porcine peripheral blood mononuclear cell (PBMC)-derived macrophages (MPhi)
I
Intervention
Infection with wild-type Classical Swine Fever Virus (CSFV) or mutant CSFV lacking the Npro gene (DeltaNpro CSFV)
C
Comparator
Mock infection or comparison between wild-type and DeltaNpro CSFV
O
Outcome
Cellular antiviral defense mechanisms, specifically resistance to poly(IC)-induced apoptosis and type I interferon (IFN) synthesissurrogate

The CSFV Npro gene is essential for the virus to evade the host's cellular innate immune system by inhibiting apoptosis and type I interferon production.

Cite This Study

Ruggli et al. (2003) studied this question.

synapsesocial.com/papers/6a7059c635aa2c282ce1a810https://doi.org/10.1128/jvi.77.13.7645-7654.2003
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Classical Swine Fever Virus Leader Proteinase N pro Is Not Required for Viral Replication in Cell Culture1998 · 93 citations
  2. 2Processing of pestivirus polyprotein: cleavage site between autoprotease and nucleocapsid protein of classical swine fever virus1993 · 165 citations
  3. 3Interference Between Strains of Bovine Virus Diarrhea Virus and Their Capacity to Suppress Interferon of a Heterologous Virus1966 · 50 citations