Population
Plasmacytoid dendritic cells (pDC)
Comparison
Wild-type Classical Swine Fever Virus infection vs Infection with CSFV mutants unable to interact…
Design
Preclinical
Authors
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Supports Npro-IRF7 manipulation in CSFV evasion; leaves open whether targeting this axis informs swine antiviral strategies.
CSFV Npro manipulates IRF7 function in plasmacytoid dendritic cells, providing an additional strategy for the virus to evade innate immunity.
Fiebach et al. (2011) studied this question.
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