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July 1, 1984Canadian Journal of Physiology and Pharmacology

Calcium and myocardial cell injury. An appraisal in the cardiomyopathic hamster

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Why the study?

Does calcium accumulation initiate or mediate myocardial cell injury in cardiomyopathic hamsters?

Population

Cardiomyopathic hamster model (hereditary cardiomyopathy)

Design

Preclinical

Authors

GJGaëtan JasminUniversité de SherbrookeLPL. ProschekUniversité de Montréal

Discussion

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Implication

Challenges primary plasmalemma defect hypothesis in hamster model; leaves open Ca2+ mediator role in human cardiomyopathy.

Structured PICO

Does calcium accumulation initiate or mediate myocardial cell injury in cardiomyopathic hamsters?

P
Population
Cardiomyopathic hamster model (hereditary cardiomyopathy)
I
Intervention
Ca2+ slow channel blockers and beta-adrenoagonists
O
Outcome
Myocardial cell injury and necrotic changessurrogate

In the cardiomyopathic hamster model, calcium accumulation appears to mediate rather than initiate myocardial degradation.

Cite This Study

Jasmin et al. (1984) studied this question.

synapsesocial.com/papers/6a705a9be36a167817e21fb7https://doi.org/10.1139/y84-149

Topics

CardiomyopathyCardiac amyloidosis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium Antagonist Receptors in Cardiomyopathic Hamster: Selective Increases in Heart, Muscle, Brain1986 · 135 citations
  2. 2Alterations in calcium antagonist receptors and sodium-calcium exchange in cardiomyopathic hamster tissues.1989 · 64 citations
  3. 3Inotropic and calcium kinetic effects of calcium channel agonist and antagonist in isolated cardiac myocytes from cardiomyopathic hamsters.1990 · 46 citations
  4. 4Consequences of uncontrolled calcium entry and its prevention with calcium antagonists1983 · 61 citations
  5. 5CARDIOMYOPATHY OF HAMSTER DYSTROPHY *1979 · 90 citations