What question did this study set out to answer?

To identify the neural circuits in the central nervous system responsible for the appetite-suppressing actions of d-fenfluramine.

July 26, 2002ScienceOpen Access

Activation of Central Melanocortin Pathways by Fenfluramine

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Authors

LHLora K. HeislerUniversity of Aberdeen MCMichael A. CowleyDiscovery Institute LTLaurence H. TecottScripps Research Institute

Discussion

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Implication

Experimental study reveals that central melanocortin pathway activation mediates fenfluramine-induced appetite suppression in rodents, highlighting a selective target for obesity treatments.

Key Points

To identify the neural circuits in the central nervous system responsible for the appetite-suppressing actions of d-fenfluramine.
Conducted functional neuroanatomy and electrophysiological recordings in rodent models.
Evaluated feeding behavior and anorexic responses following d-fenfluramine exposure.
Demonstrated that d-fenfluramine-induced anorexia requires the activation of central nervous system melanocortin pathways.
Identified downstream melanocortin signaling as a mechanistic target capable of mediating selective anti-obesity effects without the cardiac risks of d-fenfluramine.

Cite This Study

Heisler et al. (2002) studied this question.

synapsesocial.com/papers/6a705ac52163a0a01bc4936d https://doi.org/10.1126/science.1072327

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July 26, 2002ScienceOpen Access

Activation of Central Melanocortin Pathways by Fenfluramine

View Full Paper

Ask AI

Bookmark

Authors

LHLora K. HeislerUniversity of Aberdeen MCMichael A. CowleyDiscovery Institute LTLaurence H. TecottScripps Research Institute

Discussion

Member takes

Implication

Experimental study reveals that central melanocortin pathway activation mediates fenfluramine-induced appetite suppression in rodents, highlighting a selective target for obesity treatments.

Key Points

To identify the neural circuits in the central nervous system responsible for the appetite-suppressing actions of d-fenfluramine.
Conducted functional neuroanatomy and electrophysiological recordings in rodent models.
Evaluated feeding behavior and anorexic responses following d-fenfluramine exposure.
Demonstrated that d-fenfluramine-induced anorexia requires the activation of central nervous system melanocortin pathways.
Identified downstream melanocortin signaling as a mechanistic target capable of mediating selective anti-obesity effects without the cardiac risks of d-fenfluramine.

Cite This Study

Heisler et al. (2002) studied this question.

synapsesocial.com/papers/6a705ac52163a0a01bc4936d https://doi.org/10.1126/science.1072327

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