Why the study?
Do anti-obesity drugs (dexfenfluramine, phentermine, sibutramine) alter autonomic nervous system activity in normal weight males independent of weight change?
Do anti-obesity drugs (dexfenfluramine, phentermine, sibutramine) alter autonomic nervous system activity in normal weight males independent of weight change?
Anti-obesity drugs exert distinct effects on the autonomic nervous system independent of weight change, with phentermine and sibutramine increasing sympathetic tone and dexfenfluramine decreasing both sympathetic and parasympathetic tone.
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Differential autonomic effects may influence CV safety profiles; leaves open translation to obese patients and hard outcomes.
Hirsch et al. (2000) studied this question.
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