Key result
Adiponectin selectively increased TIMP-1 expression in human monocyte-derived macrophages through IL-10 induction, without affecting MMP-9.
Adiponectin selectively increases TIMP-1 expression in human macrophages via IL-10 induction, providing a potential mechanism for its protective effects against vascular inflammation and atherosclerosis.
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May support adiponectin's anti-inflammatory role in atherosclerosis; hypothesis-generating, should not yet change practice.
Kumada et al. (2004) studied Vascular inflammation. Human recombinant adiponectin was evaluated on TIMP-1 and MMP-9 mRNA levels and secretion. Adiponectin selectively increased TIMP-1 expression in human monocyte-derived macrophages through IL-10 induction, without affecting MMP-9.
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