Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension
Why the study?
Is the eNOS Glu298Asp gene variant associated with essential hypertension?
Population
879 subjects from two independent populations in Japan: Kyoto and Kumamoto.
Comparison
Presence of eNOS gene polymorphisms… vs Absence of the variant (normotensive controls).
Design
Case-control
Authors
Discussion
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Member takes
Overview
Supports Glu298Asp as hypertension susceptibility factor; leaves open clinical utility pending larger prospective studies.
Structured PICO
Is the eNOS Glu298Asp gene variant associated with essential hypertension?
P
Population
879 subjects from two independent populations in Japan: Kyoto (n=458; 240 normotensive versus 218 hypertensive subjects) and Kumamoto (n=421; 223 normotensive versus 187 hypertensive subjects).
I
Intervention
Presence of eNOS gene polymorphisms, specifically the Glu298Asp missense variant in exon 7.
C
Comparator
Absence of the variant (normotensive controls).
O
Outcome
Presence of essential hypertension.
The Glu298Asp missense variant in the eNOS gene is significantly associated with essential hypertension, suggesting it acts as a genetic susceptibility factor.
Cite This Study
Miyamoto et al. (1998) studied this question.