Review summarizes mechanisms of oocyte aging and discusses interventions to improve fertility.
Oocyte aging is a major cause of age-related fertility decline. This Review summarizes how DNA methylation disruption, aberrant histone modifications, RNA modifications and non-coding RNA dysregulation impair chromatin integrity, meiosis, mitochondrial function and developmental competence. We further discuss epigenetic and metabolism-oriented interventions, including NAD + precursors, sirtuin activation and antioxidants, highlighting mechanistic opportunities and translational limitations for improving aged oocyte quality.
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Jia et al. (2026) studied this question.
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