Why the study?
Is lower serum testosterone associated with higher mortality and myocardial damage in men with heart failure?
Population
618 men with heart failure, mean age 65.9 years
Comparison
Serum total testosterone levels vs Comparison across testosterone quartiles
Design
Cohort
Follow-up
mean 1,281 days
Key result
Total testosterone was an independent predictor of all-cause mortality in men with heart failure (HR 0.929, p=0.042), with lower levels associated with higher mortality and myocardial damage.
Authors
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Low testosterone may aid risk stratification in men with HF; hypothesis-generating and leaves open need for trials.
Cohort (n=618)
Is lower serum testosterone associated with higher mortality and myocardial damage in men with heart failure?
Hazard Ratio: 0.929
p-value: p=0.042
Decreased serum testosterone is an independent predictor of higher all-cause mortality, myocardial damage, and lower exercise capacity in men with heart failure.
Yoshihisa et al. (2018) conducted a cohort in Heart failure (n=618). Total testosterone vs. Higher quartiles of total testosterone was evaluated on All-cause mortality (HR 0.929, p=0.042). Total testosterone was an independent predictor of all-cause mortality in men with heart failure (HR 0.929, p=0.042), with lower levels associated with higher mortality and myocardial damage.