What question did this study set out to answer?

To determine whether long-term androgen-deprivation therapy in men with prostate carcinoma causes elevated fasting glucose, increased insulin levels, and insulin resistance independent of age and BMI.

December 30, 2005Cancer

Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen‐deprivation therapy

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Authors

SBShehzad BasariaBrigham and Women's Hospital DMDenis C. MullerThe University of Melbourne MCMichael A. CarducciRutgers, The State University of New Jersey

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Implication

Cross-sectional study demonstrates elevated insulin resistance and hyperglycemia in men receiving androgen-deprivation therapy, suggesting hypogonadism directly impairs glucose regulation.

Key Points

To determine whether long-term androgen-deprivation therapy in men with prostate carcinoma causes elevated fasting glucose, increased insulin levels, and insulin resistance independent of age and BMI.
Conducted a cross-sectional study at a university-based research institution in the United States involving 53 men without a history of diabetes mellitus.
Compared three groups: men with prostate cancer on ADT for ≥12 months (n=18), age-matched men with prostate cancer not receiving ADT (n=17), and age-matched healthy controls (n=18).
After adjusting for age and BMI, fasting glucose was significantly higher in the ADT group (131.0±7.43 mg/dL) versus the non-ADT group (103.0±7.42 mg/dL, P=0.01) and controls (99.0±7.58 mg/dL, P<0.01), as were insulin levels (45.0±7.25 vs. 24.0±7.24 µU/mL [P=0.05] and 19.0±7.39 µU/mL [P=0.02]).
Insulin resistance (HOMA-IR) was markedly higher in the ADT group (17.0±2.78) compared to the non-ADT (6.0±2.77, P<0.01) and control groups (5.0±2.83, P=0.01), with serum testosterone showing a significant negative correlation with glucose, insulin, leptin, and HOMA-IR.

Cite This Study

Basaria et al. (2005) studied this question.

synapsesocial.com/papers/6a705ef0ce524a4339c41b58 https://doi.org/10.1002/cncr.21642

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Implication

Cross-sectional study demonstrates elevated insulin resistance and hyperglycemia in men receiving androgen-deprivation therapy, suggesting hypogonadism directly impairs glucose regulation.

Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen‐deprivation therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen‐deprivation therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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