Key result
Aqueous extract of seeds of Datura metel significantly reduced doxorubicin-induced cardiotoxicity in rats, evidenced by decreased ASAT activity (62.43 vs 127.29 UI/L at 300 mg/kg) and improved oxidative stress markers.
Why the study?
The study evaluated the cardioprotective effect of the aqueous extract of seeds of Datura metel on acute cardiotoxicity induced with doxorubicin in Wistar rats.
Does the aqueous extract of seeds of Datura metel protect against doxorubicin-induced acute cardiotoxicity in Wistar rats?
Does the aqueous extract of seeds of Datura metel protect against doxorubicin-induced acute cardiotoxicity in Wistar rats?
Absolute Event Rate: 62.43% vs 127.29%
p-value: p=<0.001
The aqueous extract of seeds of Datura metel demonstrates cardioprotective effects against doxorubicin-induced cardiotoxicity in a rat model, likely due to its antioxidant properties.
Hypothesis-generating in rat models; leaves open translation to human doxorubicin cardioprotection.
The current study evaluated the cardioprotective effect of the aqueous extract of seeds of Datura metel (AESDM) on the acute cardiotoxicity induced with doxorubicin in the Wistar rats. Indeed, 30 rats have been randomized then, divided into 6 groups of 5 animals each: 3 control groups (normal, negative and positive) and 3 test groups (AESDM 100, 200 and 300 mg/kg). These animals received orally, six consecutive days, 1 mL/200 g distilled water (normal and negative control), 100 mg/kg Vitamin-E (positive control), AESDM at 100, 200 and 300 mg/kg (test groups). On the seventh day of treatment, animals in the different groups excepted the normal control received a single intraperitoneal injection of 15 mg/kg doxorubicin followed respective treatments up to the tenth day of the trial period. Serum parameters (ASAT/ALAT), biochemical markers of oxidative stress (MDA, SOD, CAT, GSH) and lipid parameters (total cholesterol, triglycerides, HDL and LDL) were evaluated. Histological sections of animal hearts were prepared. The results of this study showed that treatment with AESDM resulted in a significant decrease (P ˂ 0.001) in MDA, triglycerides and LDL-cholesterol levels, ASAT/ALAT activity and a significant increase (P ˂ 0.001) in HDL-cholesterol concentration and SOD, CAT and GSH activities, compared to the negative control. Histological observation revealed that AESDM protected the heart from doxorubicin-induced damage. In conclusion, AESDM would have a cardioprotective effect that could be attributed to its antioxidant potential.
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Mbida et al. (2020) studied Doxorubicin-induced acute cardiotoxicity (n=30). Aqueous extract of seeds of Datura metel (AESDM) vs. Negative control (doxorubicin + distilled water) was evaluated on ASAT activity (UI/L) (p=<0.001). Aqueous extract of seeds of Datura metel significantly reduced doxorubicin-induced cardiotoxicity in rats, evidenced by decreased ASAT activity (62.43 vs 127.29 UI/L at 300 mg/kg) and improved oxidative stress markers.
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