Key result
The ORF2-con IHC procedure accurately detected BoAstV-CH13/NeuroS1 infections in cattle brain tissue, showing positive results only in known positive samples and not in negative controls.
Population
90 brain tissue samples from cattle
Design
Preclinical
Authors
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Supports IHC confirmation of BoAstV-CH13/NeuroS1 in known cattle samples; leaves open performance in prospective diagnostic cohorts.
The developed ORF2-con IHC procedure is an adequate and accurate tool for the detection of neurotropic bovine astrovirus (BoAstV-CH13/NeuroS1) infections in cattle.
Boujon et al. (2016) studied BoAstV-CH13/NeuroS1 infection (non-suppurative encephalitis). ORF2-con immunohistochemistry (IHC) procedure vs. Known positive/negative status was evaluated on Detection of viral antigens (diagnostic sensitivity and specificity). The ORF2-con IHC procedure accurately detected BoAstV-CH13/NeuroS1 infections in cattle brain tissue, showing positive results only in known positive samples and not in negative controls.
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