Population
In vivo and in vitro models of herpes simplex virus infection, including virus mutants
Comparison
Expression of the immediate-early IE63 gene vs Virus mutants lacking IE63 expression
Design
Preclinical
Authors
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IE63 may modulate viral mRNA processing in animal HSV models; leaves open human relevance and therapeutic targeting.
The herpes simplex virus IE63 gene plays a direct role in posttranscriptional processing by stimulating viral mRNA 3' processing.
McLauchlan et al. (1992) studied this question.
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