Population
In vitro model of herpes simplex virus type 1 infection
Comparison
IE63 mutant virus 27-lacZ and mutant virus 110C1 vs Wild-type virus / presence of IE63 expression
Design
Preclinical
Authors
Loading...
IE63 may regulate HSV-1 transcript export; leaves open its therapeutic targeting pending human validation.
The HSV-1 IE63 protein is involved in regulating the nucleocytoplasmic transport of viral transcripts, specifically affecting the nuclear retention of intron-containing transcripts.
Phelan et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: