February 27, 2003Journal of VirologyOpen Access

The Domains of Glycoprotein D Required To Block Apoptosis Induced by Herpes Simplex Virus 1 Are Largely Distinct from Those Involved in Cell-Cell Fusion and Binding to Nectin1

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Population

Cells infected with herpes simplex virus 1 (HSV-1) gD deletion viruses (gD(-/-) and gD(-/+))

Comparison

Expression of gD insertion-deletion mutants vs Wild-type gD

Design

Preclinical

Authors

GZGuoying ZhouSun Yat-sen University EAElisa AvitabileUniversity of Bologna GCGabriella Campadelli‐FiumeUniversity of Bologna

Discussion

Member takes

Implication

Distinguishes separable anti-apoptotic domains in HSV-1 gD; leaves open targeted modulation in infection models.

Structured PICO

Population

Cells infected with herpes simplex virus 1 (HSV-1) gD deletion viruses (gD(-/-) and gD(-/+))

Intervention

Expression of gD insertion-deletion mutants

Comparator

Wild-type gD

Outcome

Ability to block apoptosis and mediate cell-cell fusion

The domains of HSV-1 glycoprotein D required to block apoptosis are largely distinct from those involved in cell-cell fusion and receptor binding, and glycosylation is required for the anti-apoptotic function.

Cite This Study

Zhou et al. (2003) studied this question.

synapsesocial.com/papers/6a7061636c240de38cdbc754 https://doi.org/10.1128/jvi.77.6.3759-3767.2003

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The Domains of Glycoprotein D Required To Block Apoptosis Induced by Herpes Simplex Virus 1 Are Largely Distinct from Those Involved in Cell-Cell Fusion and Binding to Nectin1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Domains of Glycoprotein D Required To Block Apoptosis Induced by Herpes Simplex Virus 1 Are Largely Distinct from Those Involved in Cell-Cell Fusion and Binding to Nectin1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider