Population
Pacemaker cells isolated from the rabbit sinoatrial node
Comparison
Ischemic-like Tyrode solution and acidic Tyrode… vs Normal Tyrode solution
Design
Preclinical
Authors
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No immediate clinical implications for ischemic arrhythmias; extends animal models of SA node dysfunction beyond Na/H exchange.
Ischemia-induced changes in sinoatrial node pacemaker cell electrical activity are primarily driven by acidosis and reduction of inward-rectifying outward K currents, rather than Na/H exchange.
Gryshchenko et al. (2002) studied this question.
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