Key result
Despite maximal surgical resection and adjuvant radiotherapy, the patient developed two non-contiguous recurrences of primary intracranial myxofibrosarcoma with progressive histological upgrading within three years.
Why the study?
Primary intracranial myxofibrosarcoma is an exceedingly rare mesenchymal malignancy with only a few cases reported.
Population
One 34-year-old male with a right frontal lobe MFS
Design
Case report and review of the literature
Authors
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Alerts clinicians to aggressive recurrence risk in rare intracranial myxofibrosarcoma; leaves open optimal adjuvant strategies pending prospective data.
Case Report (n=1)
No
This case highlights the aggressive nature, potential for cerebrospinal fluid-mediated dissemination, and stepwise histological upgrading of primary intracranial myxofibrosarcoma, emphasizing the need for long-term comprehensive follow-up.
Wen et al. (2026) conducted a case report in Primary intracranial myxofibrosarcoma (n=1). Surgical resection and adjuvant radiotherapy was evaluated on Tumor recurrence and histopathological progression. Despite maximal surgical resection and adjuvant radiotherapy, the patient developed two non-contiguous recurrences of primary intracranial myxofibrosarcoma with progressive histological upgrading within three years.
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