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August 1, 1981Anesthesiology

Effect of Spinal Anesthesia on Adrenergic Tone and the Neuroendocrine Responses to Surgical Stress in Humans

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Why the study?

Does spinal anesthesia alter adrenergic tone and neuroendocrine responses to surgical stress compared to inhalation anesthesia in surgical patients?

Population

34 human patients undergoing surgery (n=24 receiving spinal anesthesia, n=10 receiving inhalation anesthesia)

Comparison

Spinal anesthesia vs Inhalation anesthesia (halothane-nitrous oxide)

Design

Cohort

Follow-up

Postoperative recovery period

Authors

APA. Eugene PtlugJHJeffrey B. HalterNational University of Singapore

Discussion

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Implication

Spinal anesthesia was associated with level-dependent blunting of neuroendocrine stress responses; leaves open whether this improves clinical outcomes versus inhalation anesthesia.

Structured PICO

Does spinal anesthesia alter adrenergic tone and neuroendocrine responses to surgical stress compared to inhalation anesthesia in surgical patients?

P
Population
34 human patients undergoing surgery (n=24 receiving spinal anesthesia, n=10 receiving inhalation anesthesia)
I
Intervention
Spinal anesthesia (high thoracic dermatome or low spinal anesthesia)
C
Comparator
Inhalation anesthesia (halothane-nitrous oxide)
O
Outcome
Plasma levels of norepinephrine (NE) and epinephrine (EPI)surrogate

Spinal anesthesia prevents the neuroendocrine responses to surgical stress by blocking neural afferents from the site of tissue injury, with the effect on adrenergic tone depending on the cord level of anesthesia.

Cite This Study

Ptlug et al. (1981) studied this question.

synapsesocial.com/papers/6a706384ac440176ef290d35https://doi.org/10.1097/00000542-198108000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Plasma Catecholamine Increases During Surgical Stress in Man1977 · 285 citations
  2. 2Effect of Spinal Anesthesia on Adrenergic Tone and the Neuroendocrine Responses to Surgical Stress in Humans1982 · 46 citations
  3. 3Influence of Spinal and General Anesthesia on the Metabolic, Hormonal, and Hemodynamic Response in Elective Surgical Patients2014 · 70 citations
  4. 4Relationship of Impaired Insulin Secretion during Surgical Stress to Anesthesia andCatecholamine Release*1980 · 85 citations
  5. 5Influence of Epidural Analgesia on the Catecholamine and Cyclic AMP Responses to Surgery1980 · 98 citations