Why the study?
Does SLV320 reduce myocardial fibrosis and albuminuria in a rat model of 5/6 nephrectomy?
Does SLV320 reduce myocardial fibrosis and albuminuria in a rat model of 5/6 nephrectomy?
The selective adenosine A1 receptor antagonist SLV320 suppresses cardiac fibrosis and attenuates albuminuria in a rat model of chronic renal failure, suggesting potential benefits for uraemic cardiomyopathy.
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Hypothesis-generating for A1 antagonism in uremic cardiomyopathy; human translation untested and should not change practice.
Kalk et al. (2007) studied this question.
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