Why the study?
Does adenosine reduce LPS-induced TNF-alpha secretion in left ventricular muscle strips from patients with end-stage heart failure?
Population
Left ventricular muscle strips from 7 patients with end-stage congestive heart failure undergoing heart…
Comparison
Adenosine, selective adenosine A2 receptor… vs Control (absence of adenosine/DPMA/ITu)
Design
Preclinical
Authors
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Should not yet change HF practice; leaves open adenosine signaling as anti-TNF target in human myocardium.
Does adenosine reduce LPS-induced TNF-alpha secretion in left ventricular muscle strips from patients with end-stage heart failure?
Adenosine and its analogs significantly inhibit TNF-alpha release in failing human heart tissue, suggesting a potential pharmacological target for heart failure.
Wagner et al. (1998) studied this question.
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