Key result
CRT is linked to consistent improvements in LVEF and NYHA class in chemotherapy-induced cardiomyopathy.
Why the study?
With the increasing incidence of chemotherapy-induced cardiomyopathy (CIC), the efficacy of cardiac resynchronization therapy in this population needed assessment.
Does cardiac resynchronization therapy improve left ventricular ejection fraction in patients with chemotherapy-induced cardiomyopathy?
Systematic Review (n=169)
Does cardiac resynchronization therapy improve left ventricular ejection fraction in patients with chemotherapy-induced cardiomyopathy?
Cardiac resynchronization therapy appears to be an effective strategy to reverse left ventricular dysfunction in patients with chemotherapy-induced cardiomyopathy, though high-quality controlled trials are needed.
May support CRT consideration in chemotherapy-induced cardiomyopathy; extends observational data but leaves open need for RCTs.
OBJECTIVE: The aim of the study was to assess the efficacy of cardiac resynchronization therapy (CRT) in patients with chemotherapy-induced cardiomyopathy (CIC). METHODS: With the increasing incidence of CIC, the association of CRT with improvement in clinical outcomes, echocardiographic parameters, and New York Heart Classification (NYHA) class was assessed through this qualitative systematic review. RESULTS: The five studies included a total of 169 patients who underwent CRT after CIC, and of these, 61 (36.1%) patients were males. All studies showed an improvement in left ventricular ejection fraction (LVEF), among other echocardiographic parameters of LV volume. However, these findings are limited by short follow-up periods, small sample sizes, and the absence of a control group. CONCLUSION: CRT was associated with improvement in all patient parameters with CIC.
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Shehram et al. (2023) conducted a systematic review in Chemotherapy-induced cardiomyopathy (CIC) (n=169). Cardiac resynchronization therapy (CRT) was evaluated on Improvement in left ventricular ejection fraction (LVEF). Cardiac resynchronization therapy was associated with consistent improvements in left ventricular ejection fraction and NYHA functional class in chemotherapy-induced cardiomyopathy.
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