Changes in Electrocardiogram Parameters Rats Under the Influence of Acetylsalicylic Acid and Its Complex Compounds With Metals

The effect of acetylsalicylic acid (ASA) and its complex compounds with cobalt, zinc, nickel and manganese met- als at doses of 5, 10 and 20 mg/kg on the electrocardiographic parameters of rats was studied. It was shown that after administration of ASA and the tested salicylates to animals in all the studied doses, there was a statistically significant increase in the duration of the QRS complex relative to the values of this indicator in the control group of animals, most pronounced after administration of cobalt salicylate at a dose of 20 mg/kg both relative to the values of this indicator in the control group and in animals treated with ASA. The analysis of the duration of the QT interval also showed an increase in this indicator in animals of all groups, but the most pronounced after the introduction of manganese salicy- late. It was found that the tested salicylates have not only more pronounced, but often qualitatively new cardiotropic effects compared to ASA.