Key result
Men with spouses in the stage 2 obesity trajectory had a significantly higher risk of hypertension compared to those with normal-weight spouses (OR 1.54).
Why the study?
Given the dynamic nature of BMI and its role in cardiovascular risk, the study aimed to evaluate women's life-course BMI trajectories and their association with cardiovascular risk factors.
Does women's obesity trajectory increase the risk of cardiovascular risk factors in themselves, their spouses, and their offspring?
Cohort (n=5,688)
No
Does women's obesity trajectory increase the risk of cardiovascular risk factors in themselves, their spouses, and their offspring?
Odds Ratio: 1.54 (95% CI 1.05–2.25)
Absolute Event Rate: 53.4% vs 30.6%
p-value: p=<0.05
Women's obesity trajectories are significantly associated with increased cardiovascular risk factors not only in themselves but also in their spouses and offspring, highlighting the need for family-based prevention strategies.
Spousal obesity trajectories may signal men's hypertension risk; hypothesis-generating and requires prospective confirmation before clinical consideration.
Considering the dynamic nature of body mass index (BMI) and its importance in determining cardiovascular risks, this study aimed to investigate the life-course trajectory pattern of women's BMI and its association with cardiovascular risk factors. A total of 1356 couples with 2976 children were recruited and followed up for an average period of 20 years. Latent growth curve modeling was applied to determine women's BMI trajectories; logistic regression was used to investigate the associations between trajectory patterns and cardiovascular risk factors, including hypertension (HTN), dyslipidemia, diabetes mellitus (DM), and obesity. Women were classified into three trajectories, including normal, stage 1 obesity, and stage 2 obesity. Compared to women's in the normal trajectory group, those in obesity trajectories had higher odds ratios for HTN, DM, and dyslipidemia. Men with obese spouses showed a higher rate of HTN 1.54 (95% CI 1.05-2.25) and DM 1.55; (95% CI 1.00-2.44). The odds of men's obesity were higher in obese spouses (OR 1.70; 95% CI 1.10-2.62). Offspring of stage 2 obese (OR 2.39; 95% CI 1.67-3.44) and stage 1 obese (OR 4.81; 95% CI 3.16-7.34) mothers were more likely to be obese. Our findings emphasized paying more attention to women with excessive weight to promote familial cardiovascular health in the communities.
No takes yet. Share an insight, caveat, or question.
Naseri et al. (2021) conducted a cohort in Cardiovascular risk factors (n=5,688). Women's obesity trajectories (Stage 1 and Stage 2) vs. Normal BMI trajectory was evaluated on Hypertension in husbands of women with stage 2 obesity (OR 1.54, 95% CI 1.05-2.25, p=<0.05). Men with spouses in the stage 2 obesity trajectory had a significantly higher risk of hypertension compared to those with normal-weight spouses (OR 1.54).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: