Why the study?
Does intravenous nitroglycerin combined with N-acetylcysteine reduce chest pain and acute myocardial infarction in patients with severe unstable angina pectoris unresponsive to conventional treatment?
Population
46 patients with severe unstable angina pectoris unresponsive to conventional treatment
Comparison
Intravenous nitroglycerin combined with… vs Intravenous NTG alone (with placebo)
Design
RCT, double-blind
Authors
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Reduces myocardial infarction in refractory unstable angina; extends randomized evidence for nitroglycerin-N-acetylcysteine combination despite hypotension risk.
Does intravenous nitroglycerin combined with N-acetylcysteine reduce chest pain and acute myocardial infarction in patients with severe unstable angina pectoris unresponsive to conventional treatment?
Combining intravenous nitroglycerin with N-acetylcysteine significantly reduced the incidence of acute myocardial infarction in patients with refractory unstable angina, though it increased the risk of symptomatic hypotension.
Horowitz et al. (1988) studied this question.
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