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December 1, 1987Annals of Pharmacotherapy

Prevention of Recurrent Myocardial Infarction and Sudden Death with Aspirin Therapy

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Why the study?

Does aspirin reduce recurrent myocardial infarction and death in patients with MI or unstable angina?

Population

Patients with myocardial infarction (MI) or unstable angina

Comparison

Aspirin 325 mg once daily vs Placebo

Design

Review

Authors

MRMartha M. RumoreFundación Juan MarchGGGeorge S. GoldsteinNew Mexico Department of Health

Discussion

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Implication

Supports aspirin 325 mg daily for secondary prevention post-MI; leaves open need for updated RCTs in contemporary populations.

Structured PICO

Does aspirin reduce recurrent myocardial infarction and death in patients with MI or unstable angina?

P
Population
Patients with myocardial infarction (MI) or unstable angina
I
Intervention
Aspirin 325 mg once daily
C
Comparator
Placebo
O
Outcome
Recurrent myocardial infarction and deathhard clinical

Aspirin 325 mg daily is an effective and well-tolerated therapy for the secondary prevention of recurrent MI and death in patients with a history of MI or unstable angina.

Cite This Study

Rumore et al. (1987) studied this question.

synapsesocial.com/papers/6a7064438031ec7bb1dc4e26https://doi.org/10.1177/106002808702101204
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Randomized, Controlled Trial of Aspirin in Persons Recovered From Myocardial Infarction1980 · 483 citations
  2. 2The Optimal Antithrombotic Dose of Aspirin1985 · 12 citations
  3. 3Persantine Aspirin Trial in cerebral ischemia. Part II: Endpoint results. The American-Canadian Co-Operative Study group.1985 · 287 citations
  4. 4Pharmacology of platelet inhibition in humans: implications of the salicylate-aspirin interaction.1985 · 103 citations
  5. 5Effects of Low‐Dose Aspirin on Responses to Furosemide1986 · 14 citations