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February 15, 1980JAMA

A randomized, controlled trial of aspirin in persons recovered from myocardial infarction

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Why the study?

Does aspirin 1 g per day reduce total mortality in men and women who have recovered from a myocardial infarction?

Population

4,524 men and women between the ages of 30 and 69 years who had experienced at least one documented…

Comparison

Aspirin 1 g per day vs Placebo

Design

RCT, randomized, double-blind

Follow-up

3 years

Discussion

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Implication

1 g daily aspirin does not reduce post-MI mortality; challenges routine high-dose use and supports lower-dose trials.

Key Points

  • To determine the effect of regular aspirin administration on total mortality in individuals who have recovered from myocardial infarction.
  • Multicenter, randomized, double-blind, placebo-controlled trial
  • 4,524 participants aged 30-69 assigned to 1 g aspirin daily (2,267) or placebo (2,257)
  • Follow-up period of three years with high patient compliance
  • Total mortality rates were 10.8% for aspirin versus 9.7% for placebo over the entire follow-up period
  • Three-year total mortality was 9.6% in the aspirin group versus 8.8% in the placebo group
  • Definite nonfatal MI rates were 6.3% in the aspirin group compared to 8.1% in the placebo group

Structured PICO

Does aspirin 1 g per day reduce total mortality in men and women who have recovered from a myocardial infarction?

P
Population
4,524 men and women between the ages of 30 and 69 years who had experienced at least one documented myocardial infarction (MI)
I
Intervention
Aspirin 1 g per day
C
Comparator
Placebo
O
Outcome
Total mortality over a three-year periodhard clinical

Routine administration of 1 g/day of aspirin did not reduce total mortality in patients who survived a myocardial infarction and significantly increased gastrointestinal side effects.

Cite This Study

A 1980 study studied this question.

synapsesocial.com/papers/6a7288c2ac440176ef2ab89dhttps://doi.org/10.1001/jama.243.7.661
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Randomized, Controlled Trial of Aspirin in Persons Recovered From Myocardial Infarction1980 · 483 citations
  2. 2Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina1983 · 1,713 citations
  3. 3Aspirin and Recurrent Myocardial Infarction1981 · 1 citations
  4. 4Low-Dose Aspirin Therapy for Chronic Stable Angina1991 · 221 citations
  5. 5Prevention of Recurrent Myocardial Infarction and Sudden Death with Aspirin Therapy1987 · 2 citations