Key result
Blood pressure measurement using the tail cuff method in freely moving rats yielded higher reliability of consecutive values compared to ether anesthesia and restricted groups.
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Tail-cuff BP in freely moving rats may enhance reliability in rodent models; leaves open translation to clinical hypertension research.
Inconsistency in consecutive blood pressure values is one of the most frequently observed problems in tail cuff method. The aim of this study was to measure blood pressure using the tail cuff method in rats without heating, anesthesia, and movement restriction. In this study, it has been shown that blood pressure measurement could be obtained without problem using the tail cuff method in freely moving rats in their cage environment. Also, the reliability of consecutive blood pressure values obtained from freely moving rats was higher than ether anesthesia and restricted groups.
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Erken et al. (2012) studied this question. Tail cuff method without heating, anesthesia, and movement restriction vs. Ether anesthesia and restricted groups was evaluated on Reliability of consecutive blood pressure values. Blood pressure measurement using the tail cuff method in freely moving rats yielded higher reliability of consecutive values compared to ether anesthesia and restricted groups.
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