Key result
The telemetry system successfully enabled continuous and stable monitoring of cardiovascular parameters, including blood pressure, heart rate, and ECG, in unanesthetized and unrestrained F344 rats.
No direct clinical implications; leaves open validation of telemetry for cardiovascular research in translational models.
Telemetry techniques of rats have been used for assessing safety pharmacology of drugs and chemicals. Biological signals including blood pressure and heart rate measured under anesthesia were significantly different from those obtained under normal conditions. The stress of restraint in awake animals can also affect the accuracy of physiological evaluation. This paper details the surgery required to allow key cardiovascular parameters to be determined. The telemetric measurement of cardiovascular parameters such as blood pressure, heart rate, electrocardiograph(ECG) established. We carried out the continuous monitoring of cardiovascular parameters using the telemetry system in F344 rats. During the measurement, no significant changes were observed in the heart rate and blood pressure. ECG signals and body temperature were also constant during the measurement of biological signals. With the results of this study, we conclude that this telemetry system can be applied usefully for the assesment of biological parameters in the rats.
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Kim et al. (2011) studied Healthy F344 rats. Telemetry system implantation was evaluated on Continuous monitoring of cardiovascular parameters (blood pressure, heart rate, ECG). The telemetry system successfully enabled continuous and stable monitoring of cardiovascular parameters, including blood pressure, heart rate, and ECG, in unanesthetized and unrestrained F344 rats.
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