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December 1, 1993Journal of Cardiovascular Pharmacology

Telemetric Monitoring of Cardiovascular Parameters in Conscious Spontaneously Hypertensive Rats

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Why the study?

Does telemetric monitoring provide accurate cardiovascular measurements and reduce stress compared to catheter or tail-cuff methods in conscious spontaneously hypertensive rats?

Population

Male spontaneously hypertensive rats (SHR)

Comparison

Telemetric monitoring of cardiovascular parameters vs Externalized femoral arterial and venous…

Design

Preclinical

Authors

MBMichelle K. BazilLong Island UniversityCKChristine KrulanNovartis (Switzerland)RWRandy L. WebbNovartis (United States)

Discussion

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Implication

Telemetry supports lower-stress BP/HR assessment in conscious hypertensive rats; leaves open translation to human monitoring or trial endpoints.

Key Points

  • This study aims to evaluate the efficacy of telemetric monitoring for assessing cardiovascular parameters in hypertensive rats and its impact on stress levels during the process.
  • Spontaneously hypertensive rats were implanted with telemetric devices and femoral arterial catheters to obtain cardiovascular measurements.
  • Baseline blood pressure and heart rate were assessed, followed by pharmacological interventions with various agents such as phenylephrine and angiotensin I.
  • Responses were compared between telemetric measurements and those obtained via femoral arterial catheters.
  • Baseline blood pressure and heart rate values from the telemetric system were lower than those obtained from tail-cuff or femoral catheter methods.
  • Responses to intravenous nifedipine and other pharmacological agents were similar for both measurement techniques.
  • Telemetric monitoring was found to be a sensitive and accurate method with lower stress levels indicated by reduced BP responses to ACE inhibition.

Structured PICO

Does telemetric monitoring provide accurate cardiovascular measurements and reduce stress compared to catheter or tail-cuff methods in conscious spontaneously hypertensive rats?

P
Population
Male spontaneously hypertensive rats (SHR)
I
Intervention
Telemetric monitoring of cardiovascular parameters
C
Comparator
Externalized femoral arterial and venous catheters, and tail-cuff procedure
O
Outcome
Blood pressure (BP) and heart rate (HR) values at baseline and in response to pharmacological agentssurrogate

Telemetric monitoring in conscious rats is an accurate method that yields lower baseline cardiovascular values, likely due to reduced stress compared to traditional catheter or tail-cuff methods.

Cite This Study

Bazil et al. (1993) studied this question.

synapsesocial.com/papers/6a734eb764decaab472c2754https://doi.org/10.1097/00005344-199312000-00019

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of telemetry implantation surgery on blood pressure and its underlying mechanism2016 · 4 citations
  2. 2Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats2006 · 135 citations
  3. 3Measurement and Analysis of Rodent Biological Signals using Telemetry System2011
  4. 4A New Method for Continuous Chronic Measurement and Recording of Blood Pressure, Heart Rate and Activity in the Rat Via Radio-telemetry1991 · 249 citations
  5. 5Chronic exercise and its hemodynamic influences on resting blood pressure of hypertensive rats1991 · 46 citations